反应详情

温度

110 °C

A mixture of 28.8 g of 3-carbethoxy-4-hydroxy-6,7-dimethoxyquinoline and 16.6 ml of phosphorous oxychloride was stirred at 110° C. for 30 min, cooled to 0° C., and treated with a mixture of ice and ammonium hydroxide. The resulting grey solid was filtered, washed with water and ether, and dried, mp 147-150° C.

1. temperaturecooled to 0° C.
2. filtrationThe resulting grey solid was filtered
3. washwashed with water and ether
4. customdried