HCID 10594703, compound → HCID 15391002, compound

HRID 1935403Notes

Reaction equation

C(OC([N:8]1[C@@H:13]([CH2:14][CH2:15][CH2:16][CH3:17])[CH2:12][N:11]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:19]=2[CH3:25])[C:10](=[O:26])[CH2:9]1)=O)(C)(C)C>C(OCC)(=O)C>[CH2:14]([C@H:13]1[CH2:12][N:11]([C:18]2[CH:23]=[CH:22][CH:21]=[C:20]([CH3:24])[C:19]=2[CH3:25])[C:10](=[O:26])[CH2:9][NH:8]1)[CH2:15][CH2:16][CH3:17]

Participants

Conditions

Temperature: 0 °C

Procedure

A solution of the product from Step D (0.570 g, 1.58 mmol) in ethyl acetate (50 mL) was cooled to −15° C. under nitrogen. HCl gas was bubbled through for 15 min, and the reaction solution warmed to 0° C. for 2h. The solvent was removed in vacuo to provide the titled product.

Workup

customwas bubbled through for 15 min
customThe solvent was removed in vacuo

Sources & evidence

ORD record: ord-a99e841a89df45269a172638b37d1ac1
Source dataset: uspto-grants-2002_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06387903B1

Reaction notes

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