Oxalyl chloride → 5-Nitro-3-chloro-2,4-difluorobenzoyl chloride

HRID 1935560Notes

Reaction equation

HRID 1935560 reaction equation
[N+:1]([C:4]1[C:5]([F:15])=[C:6]([Cl:14])[C:7]([F:13])=[C:8]([CH:12]=1)[C:9](O)=[O:10])([O-:3])=[O:2].C(Cl)(=O)C([Cl:19])=O>ClCCl.CN(C=O)C>[N+:1]([C:4]1[C:5]([F:15])=[C:6]([Cl:14])[C:7]([F:13])=[C:8]([CH:12]=1)[C:9]([Cl:19])=[O:10])([O-:3])=[O:2]

Participants

5

Reactant 2

HCID 65578Oxalyl chlorideHCID 155499183-Chloro-2,4-difluoro-5-nitrobenzoic acid

Product 1

HCID 155499195-Nitro-3-chloro-2,4-difluorobenzoyl chloride

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideCatalystHCID 6344DichloromethaneSolvent

Procedure

An amount of 3.47 g (0.015 mole) of 5-nitro-3-chloro-2,4-difluorobenzoic acid and 2.03 g (0.016 mole) of oxalyl chloride are dissolved in 15 ml of dichloromethane then two drops of DMF are added. The reaction is stirred for 14 hours then the solvent is evaporated under vacuum to afford the desired product.

Workup

  1. customthe solvent is evaporated under vacuum

Sources & evidence

ORD record
ord-2f6a4c1a68bb42ecbc964f07babdeaae
Source dataset
uspto-grants-2002_05
Patent number
US06387928B1

Reaction notes

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