Iodoethane → 5-(3-Chloro-phenyl)-3,3-diethyl-1,3-dihydro-indol-2-one

HRID 1936932Notes

Reaction equation

HRID 1936932 reaction equation
[CH2:1]([C:3]1[C:4](=[O:12])[N:5]=[C:6]2[C:11]=1[CH:10]=[CH:9][CH:8]=[CH:7]2)[CH3:2].[CH2:13]([Li])[CH2:14][CH2:15][CH3:16].CN(C)[CH2:20][CH2:21]N(C)C.I[CH2:27][CH3:28].[NH4+].[Cl-:30]>C1COCC1>[Cl:30][C:14]1[CH:15]=[C:16]([C:9]2[CH:10]=[C:11]3[C:6](=[CH:7][CH:8]=2)[NH:5][C:4](=[O:12])[C:3]3([CH2:20][CH3:21])[CH2:1][CH3:2])[CH:27]=[CH:28][CH:13]=1

Participants

7

Reactant 5

HCID 6340IodoethaneHCID 8037N,N,N',N'-TetramethylethylenediamineHCID 25517Ammonium ChlorideHCID 219862793-Ethylindol-2-oneHCID 178418339Butyllithium

Product 1

HCID 99482465-(3-Chloro-phenyl)-3,3-diethyl-1,3-dihydro-indol-2-oneYield 45%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of 3-ethylindol-2-one (16 g, 0.1 mol) in dry THF (200 ml) under N2 was cooled to −25° C. and treated drop wise with n-butyllithium (2.5M in hexanes, 80 ml, 0.2 mol). To the resulting solution was added N,N,N′,N′-tetramethylethylenediamine (30 ml, 0.2 mol). After 30 iodoethane (8 ml, 0.1 mol) was added and the reaction mixture was allowed to warm to RT and stirred over night. The reaction mixture was poured into an aqueous NH4Cl solution, extracted with EtOAc (2×) and the combined organic layers were washed with dil. HCl, water, brine, dried (MgSO4) and concentrated. The residual oil was triturated with hexane to afford the title product (9 g, 45%), mp. 156-159° C.; 1H NMR (DMSO-d6) δ10.44 (s,1H), 7.70-7.69 (t,1H), 7.62-7.59 (m, 1H), 7.58 (d,1H J=1.7Hz), 7.53-7.50 (m, 1H), 7.45-7.41 (t,1H), 7.36-7.35 (m,1H), 7.34-7.33 (m,1H), 6.91-6.89 (d,1H, J=8.2 Hz), 1.87-1.80 (m,2H), 1.77-1.70 (m, 2H), 0.54-0.50 (t, 6H); MS (+ESI) m/z 190 (M+H).

Workup

  1. extractionextracted with EtOAc (2×)
  2. washthe combined organic layers were washed with dil. HCl, water, brine
  3. dry with materialdried (MgSO4)
  4. concentrationconcentrated
  5. customThe residual oil was triturated with hexane

Sources & evidence

ORD record
ord-57d4150be5634dde93a263af156edd33
Source dataset
uspto-grants-2002_05
Patent number
US06391907B1

Reaction notes

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