Methylamine → HCID 178482310, compound

HRID 1937028Notes

Reaction equation

HRID 1937028 reaction equation
[CH2:1]1[CH:13]2[CH:4]([C:5](=S)[NH:6][C:7]3[CH:8]=[CH:9][CH:10]=[CH:11][C:12]=32)[CH2:3][CH2:2]1.[CH3:15][NH2:16]>>[CH3:15][NH:16][C:5]1[CH:4]2[CH2:3][CH2:2][CH2:1][CH:13]2[C:12]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[N:6]=1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 10878248HCID 10878248, compound

Product 1

HCID 178482310HCID 178482310, compound

Procedure

1,2,3,3a,5,9b-Hexahydrocyclopenta[c]quinoline-4-thione (90 mg, 0.44 mmol) is stirred in 2 M methanolic methylamine solution (15 ml) for 24 hours at room temperature. After concentration by evaporation, the residue is purified on silica gel with dichloromethane-methanol: 90 mg (99%).

Workup

  1. concentrationAfter concentration
  2. customby evaporation
  3. customthe residue is purified on silica gel with dichloromethane-methanol

Sources & evidence

ORD record
ord-c25056f4c8ad42118f953227d84d7214
Source dataset
uspto-grants-2002_05
Patent number
US06391887B1

Reaction notes

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