Hydrogen Peroxide → HCID 21079465, compound

HRID 1937220Notes

Reaction equation

HRID 1937220 reaction equation
OO.[C:3]([O:22][CH:23]1[CH2:28][C:27]([CH3:30])([CH3:29])[N:26]([OH:31])[C:25]([CH3:33])([CH3:32])[CH2:24]1)(=[O:21])[CH2:4][CH2:5][CH2:6][C:7]([O:9][CH:10]1[CH2:15][C:14]([CH3:17])([CH3:16])[N:13]([OH:18])[C:12]([CH3:20])([CH3:19])[CH2:11]1)=[O:8].S([O-])([O-])=O.[Na+].[Na+].[C:40]([OH:44])([CH3:43])([CH3:42])[CH3:41]>>[C:3]([O:22][CH:23]1[CH2:28][C:27]([CH3:30])([CH3:29])[N:26]([O:31][CH2:41][C:40]([OH:44])([CH3:43])[CH3:42])[C:25]([CH3:33])([CH3:32])[CH2:24]1)(=[O:21])[CH2:4][CH2:5][CH2:6][C:7]([O:9][CH:10]1[CH2:15][C:14]([CH3:17])([CH3:16])[N:13]([O:18][CH2:41][C:40]([OH:44])([CH3:43])[CH3:42])[C:12]([CH3:20])([CH3:19])[CH2:11]1)=[O:8]

Participants

5

Reactant 4

HCID 784Hydrogen PeroxideHCID 6386tert-ButanolHCID 24437Sodium SulfiteHCID 20718399HCID 20718399, compound

Product 1

HCID 21079465HCID 21079465, compound

Procedure

Aqueous hydrogen peroxide is added to a mixture of bis(1-oxyl-2,2,6,6-tetramethylpieridin-4-yl) glutarate and ferrous chloride tetrahydrate in tert-butyl alcohol at 30-50° C. Excess peroxide is decomposed with aqeuous sodium sulfite solution. The organic layer is concentrated and the crude product is purified by flash chromatography on silica gel to afford the title compound.

Workup

  1. concentrationThe organic layer is concentrated
  2. customthe crude product is purified by flash chromatography on silica gel

Sources & evidence

ORD record
ord-13a46afa9d1d43848e1dfa1c8b9421d0
Source dataset
uspto-grants-2002_05
Patent number
US06392041B1

Reaction notes

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