Hydrochloric Acid → HCID 22460854, compound

HRID 1937385Notes

Reaction equation

HRID 1937385 reaction equation
O[C:2]1[C:3]2[CH:11]=[N:10][C:9]([CH3:12])=[CH:8][C:4]=2[N:5]=[CH:6][N:7]=1.[Cl:13][C:14]1[CH:15]=[C:16]([CH:18]=[CH:19][CH:20]=1)[NH2:17].Cl>N1C=CC=CC=1>[ClH:13].[Cl:13][C:14]1[CH:15]=[C:16]([NH:17][C:2]2[C:3]3[CH:11]=[N:10][C:9]([CH3:12])=[CH:8][C:4]=3[N:5]=[CH:6][N:7]=2)[CH:18]=[CH:19][CH:20]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 79323-ChloroanilineHCID 178422323HCID 178422323, compound

Product 1

HCID 22460854HCID 22460854, compoundYield 34%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Utilizing a procedure analogous to that described in Example 16, this product was prepared in 34% yield from 4-hydroxy-7-methyl-pyrido[4,3-d]pyrimidine (1.0 eq) and m-chloroaniline (40.0 eq) in pyridine. The HCl salt was generated from the purified free base according to the procedure given in Example 1. (M.P. 255-256° C.; GC-MS: 270 (MH+); anal. RP18-HPLC RT: 4.05 min.)

Sources & evidence

ORD record
ord-58567da7d1834ce8bdf19dbc08b3156b
Source dataset
uspto-grants-2002_05
Patent number
US06395733B1

Reaction notes

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