HCID 22461188, compound → HCID 9865125, compound

HRID 1937446Notes

Reaction equation

HRID 1937446 reaction equation
[C:1]([C:5]1[CH:31]=[CH:30][C:8]([C:9]([NH:11][C:12]2[CH:13]=[C:14]([CH:18]3[CH2:22][CH2:21][CH2:20][N:19]3C(OC(C)(C)C)=O)[CH:15]=[CH:16][CH:17]=2)=[O:10])=[C:7]([O:32][CH3:33])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2]>CO.Cl>[C:1]([C:5]1[CH:31]=[CH:30][C:8]([C:9]([NH:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([CH:18]3[CH2:22][CH2:21][CH2:20][NH:19]3)[CH:13]=2)=[O:10])=[C:7]([O:32][CH3:33])[CH:6]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

4

Reactant 1

HCID 22461188HCID 22461188, compound

Product 1

HCID 9865125HCID 9865125, compoundYield 109.5%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 887MethanolSolvent

Procedure

A solution of (±)-2-[3-(4-tert-butyl-2-methoxy-benzoylamino)-phenyl]-1-(tert-butyloxycarbonyl)-pyrrolidine (0.034 g) in methanol (3 mL) and 5M HCl (2 mL) was allowed to stir at room temperature for 18 h. Evaporation in vacuo gave the title compound as a colourless solid (0.029 g).

Workup

  1. customEvaporation in vacuo

Sources & evidence

ORD record
ord-f3bc319d5fcf4548afa567abfc6f7341
Source dataset
uspto-grants-2002_05
Patent number
US06395759B1

Reaction notes

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