Dimethylformamide → 3-(5-formyl-4-methyl-1H-pyrrol-3-yl)propanoic acid

Temperature

0 °C

Dimethylformamide was charged to a 500 mL, 3 neck round bottom flask equipped with mechanical stirring, a thermometer and a dropping funnel and maintained under a nitrogen atmosphere. The flask was cooled to 0° C. and 58.4 mL of phosphorus oxychloride was added dropwise over 80 minutes. Dichloroethane (280 mL) was added and the mixture allowed to warm to room temperature and then cooled to −10° C. 3-(2-methoxycarbonylethyl)-4-methylpyrrole (55.7 g) dissolved in 80 mL dichloroethane was added dropwise over 1 hour and the mixture stirred for another 35 minutes. The mixture was rotary evaporated at <30° C. The fluid residue was poured into 2700 mL of ice-cold 2 N sodium hydroxide solution. The resulting solution was heated to 88° C. over 20 minutes and then maintained at this temperature for an additional 30 minutes. The solution was cooled to ambient temperature and extracted with 200 mL of ethyl ether. The aqueous solution was cooled to 0° C. and acidified to pH 3.5 by slowly adding about 1350 mL of 5 N hydrochloric acid. The yellow precipitate was collected by vacuum filtration, washed four times with 100 mL of water, and dried in a vacuum oven at ambient temperature to give 54.4 g (90.2% yield) of crude 4-(2-carboxyethyl)-2-formyl-3-methylpyrrole.

1. customequipped with mechanical stirring
2. temperaturea thermometer and a dropping funnel and maintained under a nitrogen atmosphere
3. temperatureto warm to room temperature
4. temperaturecooled to −10° C
5. additionwas added dropwise over 1 hour
6. customThe mixture was rotary evaporated at <30° C
7. additionThe fluid residue was poured into 2700 mL of ice-cold 2 N sodium hydroxide solution
8. temperatureThe resulting solution was heated to 88° C. over 20 minutes
9. temperaturemaintained at this temperature for an additional 30 minutes
10. temperatureThe solution was cooled to ambient temperature
11. extractionextracted with 200 mL of ethyl ether
12. temperatureThe aqueous solution was cooled to 0° C.
13. additionby slowly adding about 1350 mL of 5 N hydrochloric acid
14. filtrationThe yellow precipitate was collected by vacuum filtration
15. washwashed four times with 100 mL of water
16. customdried in a vacuum oven at ambient temperature

ORD record

ord-cefed335651b427f94771408996ccf6f

Source dataset

uspto-grants-2002_05

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06395734B1