Dichloromethane → 9H-fluoren-9-ylmethyl 3-amino-5-[cyclopropyl-[[1-(3-methoxypropyl)indol-3-yl]methyl]carbamoyl]piperidine-1-carboxylate

HRID 193764Notes

Reaction equation

HRID 193764 reaction equation
[CH:53]1([NH:54][CH2:55][c:56]2[c:57]3[c:58]([cH:59][cH:60][cH:61][cH:62]3)[n:63]([CH2:64][CH2:65][CH2:66][O:67][CH3:68])[cH:69]2)[CH2:70][CH2:71]1.[Cl:92][CH2:93][Cl:94].[F:80][C:81]([F:82])([F:83])[S:84]([O:85][Si:86]([CH3:87])([CH3:88])[CH3:89])(=[O:90])=[O:91].[cH:1]1[cH:2][cH:3][cH:4][c:5]2[c:13]1[CH:12]([CH2:14][O:15][C:16](=[O:17])[N:18]1[CH2:19][CH:20]([NH:45][C:46]([O:47][C:48]([CH3:49])([CH3:50])[CH3:51])=[O:52])[CH2:21][CH:22]([C:24]([N:25]([CH2:26][c:27]3[cH:28][n:29]([CH2:36][CH2:37][CH2:38][O:39][CH3:40])[c:30]4[cH:31][cH:32][cH:33][cH:34][c:35]34)[CH:41]3[CH2:42][CH2:43]3)=[O:44])[CH2:23]1)[c:11]1[c:6]-2[cH:7][cH:8][cH:9][cH:10]1.[n:72]1[c:73]([CH3:74])[cH:75][cH:76][cH:77][c:78]1[CH3:79]>>[cH:1]1[cH:2][cH:3][cH:4][c:5]2[c:13]1[CH:12]([CH2:14][O:15][C:16](=[O:17])[N:18]1[CH2:19][CH:20]([NH2:45])[CH2:21][CH:22]([C:24]([N:25]([CH2:26][c:27]3[cH:28][n:29]([CH2:36][CH2:37][CH2:38][O:39][CH3:40])[c:30]4[cH:31][cH:32][cH:33][cH:34][c:35]34)[CH:41]3[CH2:42][CH2:43]3)=[O:44])[CH2:23]1)[c:11]1[c:6]-2[cH:7][cH:8][cH:9][cH:10]1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 79372,6-LutidineHCID 65367Trimethylsilyl triflateHCID 59817701cyclopropyl-[1-(3-methoxy-propyl)-1H-indol-3-ylmethyl]-amineHCID 690714809H-fluoren-9-ylmethyl 3-[cyclopropyl-[[1-(3-methoxypropyl)indol-3-yl]methyl]carbamoyl]-5-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

Product 1

HCID 690642349H-fluoren-9-ylmethyl 3-amino-5-[cyclopropyl-[[1-(3-methoxypropyl)indol-3-yl]methyl]carbamoyl]piperidine-1-carboxylate

Sources & evidence

ORD record
ord-8315c0c9576c40faa4bdf186fa4f4f2a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (6/10)

Reaction notes

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