反应详情

温度

80 °C

An oven dried test tube was charged with Pd2(dba)3 (4.5 mg, 0.005 mmol), 27 (7.4 mg, 0.015 mmol), 4-chloroanisole (140 mg, 0.98 mmol), pyrrolidine (85 mg, 1.2 mmol), NaOt-Bu (135 mg, 1.4 mmol), toluene (2 mL), and purged with argon. The mixture was heated to 80° C. and stirred for 18 hours. The reaction mixture was cooled to room temperature, diluted with ether (5 mL), filtered through a plug of celite, and concentrated in vacuo. The residue was purified by flash chromatography on silica gel to give 165 mg (95%) of the title product as colorless crystals.

1. customAn oven dried test tube
2. custompurged with argon
3. temperatureThe reaction mixture was cooled to room temperature
4. additiondiluted with ether (5 mL)
5. filtrationfiltered through a plug of celite
6. concentrationconcentrated in vacuo
7. customThe residue was purified by flash chromatography on silica gel