Piperidine → HCID 178501344, compound

HRID 1937886Notes

Reaction equation

HRID 1937886 reaction equation
C1CCNCC1.COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(Br)c3C2)CN1C(=O)OC(C)(C)C>C1COCCO1.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ccccc1-c1[c-]cccc1.[Cl][Pd+].[Li+]>COC(=O)[C@@H]1C[C@@H](OC(=O)N2Cc3c(F)ccc(N4CCCCC4)c3C2)CN1C(=O)OC(C)(C)C

Participants

6

Reactant 2

HCID 8082PiperidineHCID 1547282651-(tert-Butyl) 2-methyl (2S,4R)-4-((4-bromo-7-fluoroisoindoline-2-carbonyl)oxy)pyrrolidine-1,2-dicarboxylate

Product 1

HCID 178501344HCID 178501344, compoundYield 19%

Reagents, catalysts & solvents 3

HCID 2733832Lithium HexamethyldisilazideReagentHCID 771465301375325-68-0CatalystHCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-ff5567fa58024fba9d35db776253d52e
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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