Piperidine → HCID 178462864, compound

HRID 1937894Notes

Reaction equation

HRID 1937894 reaction equation
C1CCNCC1.CCn1c(=O)c2c(nc(N[C@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(Br)c2)n(CCO)c1=O>C1COCCO1.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.C[Si](C)(C)[N-][Si](C)(C)C.Nc1ccccc1-c1[c-]cccc1.[Cl][Pd+].[Li+]>CCn1c(=O)c2c(nc(N[C@H]3CCC[C@H]3O)n2Cc2ccc(OC)c(N3CCCCC3)c2)n(CCO)c1=O

Participants

6

Reactant 2

HCID 8082PiperidineHCID 129360362HCID 129360362, compound

Product 1

HCID 178462864HCID 178462864, compoundYield 55%

Reagents, catalysts & solvents 3

HCID 2733832Lithium HexamethyldisilazideReagentHCID 771465301375325-68-0CatalystHCID 312751,4-DioxaneSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-ea2c12982dfb4388b50140a811a7e7ef
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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