Piperidine → HCID 178474765, compound

HRID 1937916Notes

Reaction equation

HRID 1937916 reaction equation
C1CCNCC1.CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(Cl)c(C)cc21>CC(C)(C)O.CC(C)Oc1cccc(OC(C)C)c1-c1ccccc1P(C1CCCCC1)C1CCCCC1.Nc1ccccc1-c1[c-]cccc1.O=C([O-])[O-].[Cl][Pd+].[K+].[K+]>CC(=O)NC(C)(C)[C@@H]1CC2(CCN(C(=O)OC(C)(C)C)CC2)c2cc(N3CCCCC3)c(C)cc21

Participants

6

Reactant 2

HCID 8082PiperidineHCID 24805585tert-Butyl (R)-3-(2-acetamidopropan-2-yl)-6-chloro-5-methyl-2,3-dihydrospiro[indene-1,4'-piperidine]-1'-carboxylate

Product 1

HCID 178474765HCID 178474765, compoundYield 16%

Reagents, catalysts & solvents 3

HCID 11430Potassium CarbonateReagentHCID 771465301375325-68-0CatalystHCID 6386tert-ButanolSolvent2×

Conditions

Temperature
80 °C

Workup

  1. additionNo procedure recorded

Sources & evidence

ORD record
ord-46628d1e7c3f43f3a6122403e19c3654
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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