6-Chloroindole → HCID 178522350, compound

HRID 1938041Notes

Reaction equation

HRID 1938041 reaction equation
CC1(C)OB(c2ccc(C(=O)NC3CCOC3)cc2)OC1(C)C.Clc1ccc2cc[nH]c2c1>C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1[c-]cccc1.O.O=P([O-])([O-])[O-].[Cl][Pd+].[K+].[K+].[K+]>O=C(NC1CCOC1)c1ccc(-c2ccc3cc[nH]c3c2)cc1

Participants

8

Reactant 2

HCID 871116-ChloroindoleHCID 67406324HCID 67406324, compound

Product 1

HCID 178522350HCID 178522350, compoundYield 60%

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 54727932[2-(2-Aminophenyl)phenyl]-chloro-palladium dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphaneCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
25 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-5f1d2107e96046d4aff02bf24c5dec81
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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