6-Chloroindole → HCID 178527351, compound

HRID 1938055Notes

Reaction equation

HRID 1938055 reaction equation
CC1(C)OB(c2ccc(N3CCN(S(=O)(=O)c4ccc(Cl)cc4)CC3)nc2)OC1(C)C.Clc1ccc2cc[nH]c2c1>C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1[c-]cccc1.O.O=P([O-])([O-])[O-].[Cl][Pd+].[K+].[K+].[K+]>O=S(=O)(c1ccc(Cl)cc1)N1CCN(c2ccc(-c3ccc4cc[nH]c4c3)cn2)CC1

Participants

8

Reactant 2

HCID 871116-ChloroindoleHCID 179989081-(4-Chlorobenzene-1-sulfonyl)-4-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]piperazine

Product 1

HCID 178527351HCID 178527351, compoundYield 0%

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 54727932[2-(2-Aminophenyl)phenyl]-chloro-palladium dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphaneCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
60 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-c16ef1b6b931406982583fab96217229
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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