6-Chloroindole → HCID 178420769, compound

HRID 1938057Notes

Reaction equation

HRID 1938057 reaction equation
CC1(C)OB(c2ccc(-c3cccnc3)nc2)OC1(C)C.Clc1ccc2cc[nH]c2c1>C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1[c-]cccc1.O.O=P([O-])([O-])[O-].[Cl][Pd+].[K+].[K+].[K+]>c1cncc(-c2ccc(-c3ccc4cc[nH]c4c3)cn2)c1

Participants

8

Reactant 2

HCID 871116-ChloroindoleHCID 45786528HCID 45786528, compound

Product 1

HCID 178420769HCID 178420769, compoundYield 51%

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 54727932[2-(2-Aminophenyl)phenyl]-chloro-palladium dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphaneCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
60 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-8aa01b8e938b461e9299dad3749c773a
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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