6-Chloroindole → HCID 178510746, compound

HRID 1938090Notes

Reaction equation

HRID 1938090 reaction equation
CC1(C)OB(c2ccc(CC#N)nc2)OC1(C)C.Clc1ccc2cc[nH]c2c1>C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1[c-]cccc1.O.O=P([O-])([O-])[O-].[Cl][Pd+].[K+].[K+].[K+]>N#CCc1ccc(-c2ccc3cc[nH]c3c2)cn1

Participants

8

Reactant 2

HCID 871116-ChloroindoleHCID 146013706HCID 146013706, compound

Product 1

HCID 178510746HCID 178510746, compoundYield 36%

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 54727932[2-(2-Aminophenyl)phenyl]-chloro-palladium dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphaneCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
100 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-b24f5e3f83a646a1beb87dfafccf3534
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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