6-Chloroindole → HCID 178519849, compound

HRID 1938092Notes

Reaction equation

HRID 1938092 reaction equation
CC1(C)OB(c2ccc3[nH]cc(C(=O)[C@H]4CCCN4C(=O)OCc4ccccc4)c3c2)OC1(C)C.Clc1ccc2cc[nH]c2c1>C1CCOC1.CC(C)c1cc(C(C)C)c(-c2ccccc2P(C2CCCCC2)C2CCCCC2)c(C(C)C)c1.Nc1ccccc1-c1[c-]cccc1.O.O=P([O-])([O-])[O-].[Cl][Pd+].[K+].[K+].[K+]>O=C(c1c[nH]c2ccc(-c3ccc4cc[nH]c4c3)cc12)[C@H]1CCCN1C(=O)OCc1ccccc1

Participants

8

Reactant 2

HCID 871116-ChloroindoleHCID 178431022HCID 178431022, compound

Product 1

HCID 178519849HCID 178519849, compoundYield 45%

Reagents, catalysts & solvents 5

HCID 62657Potassium Phosphate, TribasicReagentHCID 54727932[2-(2-Aminophenyl)phenyl]-chloro-palladium dicyclohexyl-[2-(2,4,6-triisopropylphenyl)phenyl]phosphaneCatalystHCID 962WaterSolventHCID 8028TetrahydrofuranSolvent2×HCID 741954,4'-Bis(1,1-dimethylethyl)-1,1'-biphenylInternal standard

Conditions

Temperature
100 °C

Workup

  1. stirringNo procedure recorded

Sources & evidence

ORD record
ord-c8fd5763a00d4dc48f34070020f76287
Source dataset
Pd_CN_Coupling_Informer_Library
Original link
View source

Reaction notes

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