Methane → 2-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid

HRID 1938142Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1938142
C([O:3][C:4]([C:6]1[N:7]=[C:8]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([Cl:18])[CH:13]=2)[S:9][CH:10]=1)=[O:5])C.[OH-].[Na+].C>O>[Cl:18][C:14]1[CH:13]=[C:12]([CH:17]=[CH:16][CH:15]=1)[O:11][C:8]1[S:9][CH:10]=[C:6]([C:4]([OH:5])=[O:3])[N:7]=1

Komponenten

5

Edukt 3

HCID 297MethaneHCID 14798Sodium HydroxideHCID 214686012-(3-Chloro-phenoxy)-thiazole-4-carboxylic acid ethyl ester

Produkt 1

HCID 214686062-(3-Chloro-phenoxy)-thiazole-4-carboxylic acidAusbeute 94,7 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

A mixture of 26,36g (92.9 mmol) ethyl-2-(3-chlorophenoxy)thiazole-4-carboxylate (prepared analogously to the procedures of Example 1c), 7.5 g (187.5 mmol) NaOH and 300 ml of water was stirred 1 hour at 60° C. and 16 hours at room temperature. After adding a small amount of charcoal the yellow solution was stirred 10 minutes at room temperature and the charcoal separated by silica gel filtration. The filtrate was acidified with conc. HCl and the precipitate was collected and dried to give 22.5 g (94.7%) of 2-(3-chlorophenoxy)thiazole-4-carboxylic acid of m.p. 135°-137° C.

Aufarbeitung

  1. stirringwas stirred 10 minutes at room temperature
  2. customthe charcoal separated by silica gel filtration
  3. customthe precipitate was collected
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-9eeb861e785142f8b5a100dcaf7f3551
Quelldatensatz
uspto-grants-1997_12
Patentnummer
US05693594

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