Hydrochloric Acid → HCID 21469388, compound

HRID 1938365Notes

Reaction equation

HRID 1938365 reaction equation
Cl.[C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([F:33])[CH:31]=3)[NH:26][CH:25]=2)[CH2:20][CH2:19]1)([OH:4])=[O:3].[CH3:34]O>>[CH3:34][O:3][C:2]([C:5]1[CH:6]=[C:7]2[C:11](=[CH:12][CH:13]=1)[NH:10][CH:9]=[C:8]2[CH2:14][CH2:15][CH2:16][CH2:17][N:18]1[CH2:23][CH2:22][CH:21]([C:24]2[C:32]3[C:27](=[CH:28][CH:29]=[C:30]([F:33])[CH:31]=3)[NH:26][CH:25]=2)[CH2:20][CH2:19]1)=[O:4]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 21469386HCID 21469386, compound

Product 1

HCID 21469388HCID 21469388, compound

Procedure

HCl gas is passed into a boiling solution of 2.5 g of 3-[1-(4-(5-carboxyindol-3-yl)butyl)-4-piperidyl]-5-fluoroindole in 50 ml of absolute methanol for hours. The mixture is then boiled for a further hour, is worked up in a conventional manner and gives 3-[1-(4-(5-methoxycarbonylindol-3-yl)butyl)-4-piperidyl]-5-fluoroindole.

Workup

  1. waitThe mixture is then boiled for a further hour

Sources & evidence

ORD record
ord-9e1a4a2227824166b3fff6f268d374a4
Source dataset
uspto-grants-1997_12
Patent number
US05693655

Reaction notes

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