反应详情

A stirred solution of ethyl 2-(5-ethyl-2-pyridyl)-4-isopropyl-4-methyl-5-oxo-2-imidazoline-1-acetate (2.12 g, 6.41 mmol) in tetrahydrofuran is treated with 2N sodium hydroxide (8 mL). The resulting mixture is stirred at room temperature for 16 hours. After this period, the reaction mixture is concentrated in vacuo to obtain a residue. The residue is acidified with concentrated hydrochloric acid and then extracted with ether. The organic extract is dried over magnesium sulfate, vacuum filtered through diatomaceous earth and concentrated in vacuo to give the title product as a white solid, mp 134°-136° C.

1. waitAfter this period
2. concentrationthe reaction mixture is concentrated in vacuo
3. customto obtain a residue
4. extractionextracted with ether
5. extractionThe organic extract
6. dry with materialis dried over magnesium sulfate, vacuum
7. filtrationfiltered through diatomaceous earth
8. concentrationconcentrated in vacuo