Water → HCID 178503347, compound

HRID 1938559Notes

Reaction equation

HRID 1938559 reaction equation
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8]([SH:10])=[N:7][C:6]=2[CH:11]=1.[C:12](=O)([O-])[O-].[K+].[K+].CI.O>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]2[NH:9][C:8]([S:10][CH3:12])=[N:7][C:6]=2[CH:11]=1

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 178527794HCID 178527794, compound

Product 1

HCID 178503347HCID 178503347, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

8.89 g of 6-chloro-2-mercaptobenzimidazole was dissolved in 150 ml of dimethylformamide, followed by the addition of 6.65 g of potassium carbonate and 6.15 g of methyl iodide under cooling with ice. The obtained mixture was stirred at that temperature for 50 minutes, followed by the addition of water. The resulting mixture was extracted with ethyl acetate. The ethyl acetate layer was dried and concentrated in a vacuum to give crude 6-chloro-2-methylthiobenzimidazole.

Workup

  1. temperatureunder cooling with ice
  2. extractionThe resulting mixture was extracted with ethyl acetate
  3. dry with materialThe ethyl acetate layer was dried
  4. concentrationconcentrated in a vacuum

Sources & evidence

ORD record
ord-c1b5a05df04e41a9875deb0801f635c1
Source dataset
uspto-grants-1997_12
Patent number
US05693652

Reaction notes

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