Iodoethane → HCID 21468880, compound

HRID 1938610Notes

Reaction equation

HRID 1938610 reaction equation
[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[CH:12]2)#[N:2].[CH2:18]([Mg]Br)[CH3:19].C(I)C>C1COCC1>[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[CH:10]=[C:11]2[C:15](=[CH:16][CH:17]=1)[NH:14][CH:13]=[C:12]2[CH2:18][CH3:19])#[N:2]

Participants

5

Reactant 3

HCID 6340IodoethaneHCID 21468934HCID 21468934, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 21468880HCID 21468880, compoundYield 31.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

5- (2-cyanophenyl) indole (1.26 mmoles, 630 mg) was dissolved in THF (20 ml) and treated with ethylmagnesium bromide (1.26 mmoles, 0.630 ml) and ethyl iodide (3.45 mmoles, 0.54 g) as in Example 24 to yield 98 mg of 5-(2-cyanophenyl)-3-ethylindole. (MS)

Sources & evidence

ORD record
ord-d32cc80d66614a24a0670cfec21c81c0
Source dataset
uspto-grants-1997_12
Patent number
US05693633

Reaction notes

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