Triethylamine → HCID 21469488, compound

HRID 1938672Notes

Reaction equation

HRID 1938672 reaction equation
[C:1]([CH:3]1[CH:7]([C:8]2[NH:12][N:11]=[N:10][N:9]=2)[CH2:6][CH2:5][CH2:4]1)#[N:2].C(N(CC)CC)C.Br[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH3:32]>C(#N)C>[C:1]([CH:3]1[CH:7]([C:8]2[N:12]=[N:11][N:10]([CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH3:21])[N:9]=2)[CH2:6][CH2:5][CH2:4]1)#[N:2]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 89191-BromododecaneHCID 178509541HCID 178509541, compound

Product 1

HCID 21469488HCID 21469488, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The tetrazole (b) obtained above (11.0 g; 0.067 moles) was dissolved in acetonitrile (150 mL) containing one equivalent of triethylamine (6.8 g; 0.067 moles). The solution was heated to reflux followed by the addition of 1-bromo dodecane (16.8 g; 0.067 moles). Isolation of the 2-isomer was achieved employing the same conditions described for Example 11.

Workup

  1. temperatureThe solution was heated
  2. temperatureto reflux

Sources & evidence

ORD record
ord-c2fb38bb1ea34cfe96948421103ff4c5
Source dataset
uspto-grants-1997_12
Patent number
US05693657

Reaction notes

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