反应详情

Hydroxylamine hydrochloride (11.95 g, 0.17 mol) was added to a solution of triethylamine (23.9 mL, 0.17 mol) in 50% ethanol/water (40 mL), and the mixture was stirred with ice, cooling until the NH2OH.HCl dissolved (0.5 hour). The mixture was then diluted with ethanol (300 mL) and α-cyano-N-(2,4,6-trimethoxyphenyl)-benzene acetamide (44.9 g, 0.138 mol) added in one portion and the mixture refluxed for 8 hours, allowed to cool, and poured into water (2 L) to yield a 2-phase oil/water mixture. The aqueous phase was concentrated in vacuo and the precipitate collected. The oil phase was triturated with chloroform to yield a white solid which was combined with the previous lot to yield 33.6 g, 68%, % (found): C, 60.35; H, 6.11; N, 11.60.

1. dissolutiondissolved (0.5 hour)
2. additionadded in one portion
3. temperaturethe mixture refluxed for 8 hours
4. temperatureto cool
5. concentrationThe aqueous phase was concentrated in vacuo
6. customthe precipitate collected
7. customThe oil phase was triturated with chloroform
8. customto yield a white solid which
9. customto yield 33.6 g, 68%