Hydroxyamine hydrochloride → HCID 86751702, compound

HRID 1939144Notes

Reaction equation

HRID 1939144 reaction equation
[CH:1]([C:3]1[O:8][CH2:7][N:6]([C:9]([CH3:17])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[C:5](=[O:18])[C:4]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)=O.Cl.[NH2:26][OH:27].C([O-])(=O)C.[Na+]>C(O)C>[OH:27][N:26]=[CH:1][C:3]1[O:8][CH2:7][N:6]([C:9]([CH3:17])([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH3:10])[C:5](=[O:18])[C:4]=1[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 443297Hydroxyamine hydrochlorideHCID 517045Sodium AcetateHCID 21223275HCID 21223275, compound

Product 1

HCID 86751702HCID 86751702, compoundYield 86%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

6-Formyl-3-(1-methyl-1-phenylethyl)-5-phenyl-2,3-dihydro-4H-1,3-oxazin-4-one (Compound No. 121, 2.87 g) was dissolved in ethanol (30 ml), and an aqueous solution (15 ml) of hydroxylamine hydrochloric acid (0.65 g) and sodium acetate (1.30 g) was added slowly thereto at room temperature. After stirring for one hour, ethanol was removed by evaporation, and filtered after adding water. The solid product obtained was rinsed with water and dried to afford the captioned compound (2.59 g, yield 86%).

Workup

  1. customat room temperature
  2. customethanol was removed by evaporation
  3. filtrationfiltered
  4. additionafter adding water
  5. customThe solid product obtained
  6. washwas rinsed with water
  7. customdried

Sources & evidence

ORD record
ord-46e43874d22d41d7a1e50d96a8eba61a
Source dataset
uspto-grants-1997_12
Patent number
US05696054

Reaction notes

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