Chloroform → HCID 54414068, compound

HRID 1939282Notes

Reaction equation

HRID 1939282 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]([F:12])([F:11])[F:10])=[CH:5][C:4]=1[NH:13][C:14](Cl)=[O:15].[NH2:17][C:18]1[C:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]=2[CH:21]=[CH:20][CH:19]=1.C(N(CC)CC)C.C(Cl)(Cl)Cl>O>[C:18]1([NH:17][C:14]([NH:13][C:4]2[CH:5]=[C:6]([C:9]([F:12])([F:11])[F:10])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])=[O:15])[C:27]2[CH2:26][CH2:25][CH2:24][CH2:23][C:22]=2[CH:21]=[CH:20][CH:19]=1

Participants

6

Reactant 4

HCID 6212ChloroformHCID 8471TriethylamineHCID 166715-TetralinylamineHCID 21467366HCID 21467366, compound

Product 1

HCID 54414068HCID 54414068, compoundYield 38.6%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2-methoxy-5-(trifluoromethyl)phenyl carbamoylchloride (0.81 g, 3.2 mmol), 1-amino-5,6,7,8-tetrahydronaphtalene (445 μl, 3.2 mmol) and triethylamine (446 μl, 3.2 mmol) were added to chloroform (20 ml) and the resulting mixture was stirred at RT overnight. The reaction mixture was poured into water and extracted with ethyl acetate. The solvent was evaporated in vacuuo and the residue recrystallized from toluene (20 ml). 0.45 g of the title compound was isolated.

Workup

  1. extractionextracted with ethyl acetate
  2. customThe solvent was evaporated in vacuuo
  3. customthe residue recrystallized from toluene (20 ml)

Sources & evidence

ORD record
ord-2428f200bbd14f1da9e51da695eb33bb
Source dataset
uspto-grants-1997_12
Patent number
US05696138

Reaction notes

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