Triethylamine → HCID 70065858, compound

HRID 1939610Notes

Reaction equation

HRID 1939610 reaction equation
Cl.[CH2:2]([O:9][C:10](=[O:14])[CH2:11][NH:12][CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[N:15]1[CH:20]=[CH:19][CH:18]=[C:17]([CH2:21][C@@H:22]([C:24]([OH:26])=[O:25])[NH2:23])[CH:16]=1.[C:27]1([CH2:33][S:34](Cl)(=[O:36])=[O:35])[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1.C(N(CC)CC)C>CN(C)C=O.C(#N)C>[CH2:2]([O:9][C:10](=[O:14])[CH2:11][NH:12][CH3:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[CH2:33]([S:34]([NH:23][C@H:22]([C:24]([OH:26])=[O:25])[CH2:21][C:17]1[CH:16]=[N:15][CH:20]=[CH:19][CH:18]=1)(=[O:36])=[O:35])[C:27]1[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 74740Phenylmethanesulfonyl chlorideHCID 70064756HCID 70064756, compound

Product 1

HCID 70065858HCID 70065858, compoundYield 27%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolventHCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared under the same manner as described in Example 58, using 2.44 g (6.7 mmole) of the compound of Example 57 in 10 mL of dry dimethylformamide and 25 mL acetonitrile, alphatoluenesulfonyl chloride (1.9 g, 10.1 mmole), and triethylamine (5 mL, 34 mmole). This afforded 0.86 g (27% yield) of the title compound as a brownish-yellow foam. Rf=0.45 (1:9 methanol:dichloromethane).

Workup

  1. customThe title compound was prepared under the same manner

Sources & evidence

ORD record
ord-35fe3249dc964932964bdf72b69513dc
Source dataset
uspto-grants-1997_12
Patent number
US05696231

Reaction notes

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