HCID 21465100, compound → HCID 21465085, compound

HRID 1939888Notes

Reaction equation

HRID 1939888 reaction equation
[C:1]1([CH2:7][CH2:8][C:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH:10]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1>CCOC(C)=O.[Pd]>[C:1]1([CH2:7][CH2:8][CH:9]2[CH2:14][CH2:13][CH:12]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 1

HCID 21465100HCID 21465100, compound

Product 1

HCID 21465085HCID 21465085, compoundYield 94%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of the product of STEP 1 (1.33 g) in EtOAc (40 mL), add 10% Pd/C (0.2 g) and hydrogenate overnight at 58 psi. Filter the catalyst and concentrate the reaction mixture to give ethyl 4-(2-phenylethyl)-cyclohexanecarboxylate (1.26 g).

Workup

  1. filtrationFilter the catalyst
  2. concentrationconcentrate the reaction mixture

Sources & evidence

ORD record
ord-d6c54c6937f24196b7c2b97260da6ba6
Source dataset
uspto-grants-1997_12
Patent number
US05698548

Reaction notes

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