反应详情

A solution of 36.2 g of 1,2,3,4-tetrahydro-6-(2-(3-benzylpiperidino)-1-oxoethyl)quinolin-2-one ("A"; racemate; obtainable by reaction of 1,2,3,4-tetrahydroquinolin-2-one with chloroacetyl chloride/AlCl3 /DMF to give 6-chloroacetyl-1,2,3,4-tetrahydroquinolin-2-one ("B") and subsequent reaction with (racemic) 3-benzylpiperidine in ethanol in the presence of triethylamine) in 725 ml of methanol is treated with 3.8 g of NaBH4 and then stirred at 10° for 2 hours. Customary working up (sodium hydroxide solution/dichloromethane) gives 6-(2-(3-benzylpiperidino)-1-hydroxyethyl)-1,2,3,4-tetrahydroquinolin-2-one, racemate ("C").

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