1-Bromo-3-chloropropane → HCID 2994358, compound

HRID 1939949Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])#[N:2].Br[CH2:11][CH2:12][CH2:13]Cl.[NH:15]1[CH2:20][CH2:19][CH2:18][CH2:17][CH2:16]1>>[N:15]1([CH2:16][CH2:17][CH2:18][O:9][C:4]2[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=2[C:1]#[N:2])[CH2:20][CH2:19][CH2:13][CH2:12][CH2:11]1

Participants

Reactant 3

HCID 80061-Bromo-3-chloropropane

HCID 8082Piperidine

HCID 119072-Hydroxybenzonitrile

Product 1

HCID 2994358HCID 2994358, compoundYield 77%

Procedure

According to a similar manner as that in Reference Example 36 except that 2-cyanophenol, 1-bromo-3-chloropropane, and piperidine were used, 2-(3-piperidinopropoxy)benzonitrile (77%) was obtained as a crude product.

Sources & evidence

ORD record: ord-d162b53b415345fa86e3d50d56f07704
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698560

Reaction notes

Loading…