1-Bromo-3-chloropropane → HCID 21465376, compound

HRID 1939950Notes

Reaction equation

[C:1]([C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[OH:9])#[N:2].Br[CH2:11][CH2:12][CH2:13]Cl.[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>>[CH2:15]([N:17]([CH2:18][CH3:19])[CH2:11][CH2:12][CH2:13][O:9][C:4]1[CH:5]=[CH:6][CH:7]=[CH:8][C:3]=1[C:1]#[N:2])[CH3:16]

Participants

Reactant 3

HCID 80061-Bromo-3-chloropropane

HCID 8021Diethylamine

HCID 119072-Hydroxybenzonitrile

Product 1

HCID 21465376HCID 21465376, compoundYield 95%

Procedure

According to a similar manner as that in Reference Example 36 except that 2-cyanophenol, 1-bromo-3-chloropropane, and diethylamine were used, 2-[3-(diethylamino)propoxy]benzonitrile (95%) was obtained as a crude product.

Sources & evidence

ORD record: ord-889ce4f7d5d344cd8d911ccaf7a64ea8
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698560

Reaction notes

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