1-Bromo-3-chloropropane → HCID 21465378, compound

HRID 1939953Notes

Reaction equation

[C:1]([C:3]1[CH:4]=[C:5]([OH:9])[CH:6]=[CH:7][CH:8]=1)#[N:2].Br[CH2:11][CH2:12][CH2:13]Cl.[CH2:15]([NH:17][CH2:18][CH3:19])[CH3:16]>>[CH2:15]([N:17]([CH2:18][CH3:19])[CH2:11][CH2:12][CH2:13][O:9][C:5]1[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=1)[C:1]#[N:2])[CH3:16]

Participants

Reactant 3

HCID 80061-Bromo-3-chloropropane

HCID 8021Diethylamine

HCID 133943-Cyanophenol

Product 1

HCID 21465378HCID 21465378, compoundYield 54%

Procedure

According to a similar manner as that in Reference Example 78 except that 3-cyanophenol, 1-bromo-3-chloropropane, and diethylamine were used, 3-[3-(diethylamino)propoxy]benzonitrile (54%) was obtained as a crude product.

Sources & evidence

ORD record: ord-33f23a69c56a4159866ce421e33cf35b
Source dataset: uspto-grants-1997_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05698560

Reaction notes

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