Hydrochloric Acid → 6-(Morpholine-4-carbonyl)nicotinic acid

HRID 1940043Notes

Reaction equation

HRID 1940043 reaction equation
[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([O:15]C(C)(C)C)=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.Cl>[N+](C)([O-])=O>[N:1]1([C:7]([C:9]2[CH:21]=[CH:20][C:12]([C:13]([OH:15])=[O:14])=[CH:11][N:10]=2)=[O:8])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 100857186-(Morpholine-4-carbonyl)nicotinic acid, t-butyl ester

Product 1

HCID 101055146-(Morpholine-4-carbonyl)nicotinic acid

Reagents, catalysts & solvents 1

HCID 6375NitromethaneSolvent

Procedure

In step c, the t-butyl ester functionality of 16 is hydrolyzed, with for example, HCl in nitromethane, to give the corresponding 6-(morpholine-4-carbonyl)nicotinic acid 17.

Sources & evidence

ORD record
ord-d2592759c1c44937bc008c3b03acdaff
Source dataset
uspto-grants-1997_12
Patent number
US05698523

Reaction notes

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