Triethylamine → HCID 70185059, compound

HRID 1940220Notes

Reaction equation

HRID 1940220 reaction equation
[Cl:1][C:2]1[NH:6][C:5]([CH2:7][CH2:8][CH3:9])=[N:4][CH:3]=1.CO[CH:12]([N:15]([CH3:17])[CH3:16])OC.C(N(CC)CC)C>ClC1C=CC=CC=1>[Cl:1][C:2]1[C:3](=[CH:12][N:15]([CH3:17])[CH3:16])[N:4]=[C:5]([CH2:7][CH2:8][CH3:9])[N:6]=1

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 78373Dimethylformamide dimethyl acetalHCID 21466603HCID 21466603, compound

Product 1

HCID 70185059HCID 70185059, compound

Reagents, catalysts & solvents 1

HCID 7964ChlorobenzeneSolvent

Procedure

A solution of 5-chloro-2-propyl-1H-imidazole (0.72 g, 5 mmol), dimethoxymethyldimethylamine (0.77 g, approximately 92 percent pure, 6 mmol) and triethylamine (0.10 g, 1 mmol) in chlorobenzene (25 ml) was heated for 1 hour at 60° C. and for 2 hours under reflux. Removing the solvent in a rotavapor gave the title compound in virtually quantitative yield. Data concerning the product was:

Workup

  1. temperatureunder reflux
  2. customRemoving the solvent in a rotavapor

Sources & evidence

ORD record
ord-dc79627575fb4075ac7f749db47da27e
Source dataset
uspto-grants-1997_12
Patent number
US05698707

Reaction notes

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