Tetrahydrofuran → 3-Amino-5-chloro-4-methyl-6-(2-pyridin-4-yl-ethoxy)-thieno[2,3-b]pyridine-2-carboxylic acid cyclopropylamide
Reaction equation
[CH2:41]1[O:42][CH2:43][CH2:44][CH2:45]1.[CH3:10][Si:11]([N-:12][Si:13]([CH3:14])([CH3:15])[CH3:16])([CH3:17])[CH3:18].[CH:20]1([NH:23][C:24](=[O:25])[c:26]2[c:27]([NH2:40])[c:28]3[c:29]([n:30][c:31]([S:36]([CH3:37])=[O:38])[c:32]([Cl:35])[c:33]3[CH3:34])[s:39]2)[CH2:21][CH2:22]1.[Li+:19].[n:1]1[cH:2][cH:3][c:4]([CH2:7][CH2:8][OH:9])[cH:5][cH:6]1>>[n:1]1[cH:2][cH:3][c:4]([CH2:7][CH2:8][O:9][c:31]2[n:30][c:29]3[c:28]([c:27]([NH2:40])[c:26]([C:24]([NH:23][CH:20]4[CH2:21][CH2:22]4)=[O:25])[s:39]3)[c:33]([CH3:34])[c:32]2[Cl:35])[cH:5][cH:6]1Participants
6
Reactant 5
Product 1
Sources & evidence
- ORD record
- ord-dfb756b811684eb4b9bac34e0e212136
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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