Lithium Hydroxide → HCID 15818950, compound

HRID 1940513Notes

Reaction equation

HRID 1940513 reaction equation
Cl.Cl.[N:3]1[CH:8]=[CH:7][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([O:19]C)=[O:18])[CH2:11][CH2:10]2)=[CH:5][CH:4]=1.[OH-].[Li+].[Cl-].[NH4+]>O1CCCC1.O>[N:3]1[CH:4]=[CH:5][C:6]([N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][C:17]([OH:19])=[O:18])[CH2:11][CH2:10]2)=[CH:7][CH:8]=1

Participants

6

Reactant 3

HCID 3939Lithium HydroxideHCID 25517Ammonium ChlorideHCID 21462681HCID 21462681, compound

Product 1

HCID 15818950HCID 15818950, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolvent2×HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of 6 g (0.02 Mol) of methyl 3-[4(4-pyridyl)piperazin-1-yl]propionate dihydrochloride in 80 ml of tetrahydrofuran and 100 ml of water is added a solution of 4.2 g (0.1 Mol) of lithium hydroxide in 100 ml of water and the mixture is stirred for two hours at ambient temperature. It is then evaporated to dryness in vacuo and the residue remaining is taken up in absolute ethanol. 5.3 g (0.1 Mol) of ammonium chloride are added, the inorganic salts precipitated are suction filtered and the solution remaining is evaporated to dryness. The residue is triturated with ether and suction filtered.

Workup

  1. customIt is then evaporated to dryness in vacuo
  2. customthe inorganic salts precipitated
  3. filtrationare suction filtered
  4. customthe solution remaining is evaporated to dryness
  5. customThe residue is triturated with ether and suction
  6. filtrationfiltered

Sources & evidence

ORD record
ord-a627fcf3093447b1b4430979629670df
Source dataset
uspto-grants-1997_12
Patent number
US05700801

Reaction notes

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