反应详情

To dimethylsulfoxide (DMSO; 6 ml) was added 4,5,7-trifluoro-2-mercaptobenzothiazole (442 mg, 2 mmol), N-chloroacetyl-N-phenylglycine methyl ester (479 mg, 2 mmol), calcium carbonate (276 mg, 2 mmol) and potassium iodide (20 mg) and the mixture was stirred at room temperature for 1 hour. The resultant reaction mixture was diluted with water, acidified with 7% hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, dried and then evaporated to yield a residue, which was crystallized from isopropyl ether to give N-[2-(4,5,7-trifluorobenzothiazol-2-ylthio)acetyl]-N-phenylglycine methyl ester (700 mg, 82%) as a colorless powder.

1. customThe resultant reaction mixture
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. customdried
5. customevaporated
6. customto yield a residue, which
7. customwas crystallized from isopropyl ether