反应详情

To DMSO (15 ml) was added α-chloroacetoanilide (850 mg, 5 mmol), 4,5,7-trifluoro-2-mercaptobenzothiazole (1.1 g, 5 mmol), potassium carbonate (690 mg, 5 mmol) and potassium iodide (50 mg) and the mixture was stirred at room temperature for 4 hours. The resultant reaction mixture was diluted with water, acidified with 7% hydrochloric acid and extracted with ethyl acetate. The organic layer was washed with water, dried and then evaporated to yield a crude product, which was purified on a silica gel column to give 2-(4,5,7-trifluorobenzothiazol-2-ylthio)-N-phenylacetamide (0.97 g, 52%).

1. customThe resultant reaction mixture
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with water
4. customdried
5. customevaporated
6. customto yield a crude product, which
7. customwas purified on a silica gel column