反应详情

温度

120 °C

To N,N-dimethylformamide (50 ml) are added 3-(2-chloro-6-fluorophenyl)-5-(3-chloro-4-hydroxyphenyl)-1-methyl-1H-1,2,4-triazole (3.04 g), 2-chloro-5-trifluoromethyl pyridine (1.70 g) and potassium carbonate (1.40 g), which is heated at 120° C. for 2 hours with stirring. After cooling to room temperature, the reaction solution is poured into water and extracted with ethyl acetate, and the layer is washed with water and dried over anhydrous magnesium sulfate. After the concentration under reduced pressure, the crude solid is purified by silica gel column chromatography using mixed solution of hexane-ethyl acetate as eluent to give 3.30 g of desired compound (melting point: 116.0°-117.0° C.).

1. temperatureAfter cooling to room temperature
2. extractionextracted with ethyl acetate
3. washthe layer is washed with water
4. dry with materialdried over anhydrous magnesium sulfate
5. concentrationAfter the concentration under reduced pressure
6. customthe crude solid is purified by silica gel column chromatography
7. additionusing mixed solution of hexane-ethyl acetate as eluent