Water → HCID 21459557, compound

HRID 1940997Notes

Reaction equation

HRID 1940997 reaction equation
[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[NH:4][C:3]=1[C:9]#[N:10].[C:11](=O)([O-])[O-].[K+].[K+].CI.O>CC(C)=O.C(COC)OC>[Br:1][C:2]1[C:6]([Br:7])=[C:5]([Br:8])[N:4]([CH3:11])[C:3]=1[C:9]#[N:10]

Participants

7

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 12040166HCID 12040166, compound

Product 1

HCID 21459557HCID 21459557, compound

Reagents, catalysts & solvents 2

HCID 180AcetoneSolventHCID 80711,2-DimethoxyethaneSolvent

Procedure

3,4,5-Tribromo-pyrrole-2-carbonitrile (1.0 g, 0.003 mol) is dissolved in a mixture of acetone (20 mL) and dimethoxyethane (10 mL). potassium carbonate (0.45 g, 0.0033 mol) is added followed by methyl iodide (0.478 g, 0.0033 mol). After stirring overnight at room temperature, the mixture is poured into water precipitating a white solid. The solid (0.8 g, 80%) has mp 115°-119° C.

Sources & evidence

ORD record
ord-a6934eb800444331ac906af2975df62a
Source dataset
uspto-grants-1997_12
Patent number
US05702681

Reaction notes

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