Triphenylphosphine → HCID 178506034, compound

HRID 1941025Notes

Reaction equation

HRID 1941025 reaction equation
[F:1][CH2:2][CH2:3][CH2:4][Br:5].[C:6]1([P:12]([C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1>C1(C)C=CC=CC=1>[Br-:5].[F:1][CH2:2][CH2:3][CH2:4][PH:12]([C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 67699Propane, 1-bromo-3-fluoro-

Product 1

HCID 178506034HCID 178506034, compoundYield 85.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

3-Fluorobromopropane (200.0 g, 1.42 mol) was dissolved in toluene (3), followed by adding to the solution, triphenylphosphine (37.2 g, 1.42 mol), refluxing the mixture for 15 hours, filtering off the resulting product, and suction-drying, to obtain 3-fluoropropyltriphenylphosphine bromide (486 g, 1.21 mol). Yield: 85.2%.

Workup

  1. temperaturerefluxing the mixture for 15 hours
  2. filtrationfiltering off the resulting product
  3. customsuction-drying

Sources & evidence

ORD record
ord-e4e6cd7fe3bc460b9acc0cf9d888fa4a
Source dataset
uspto-grants-1997_12
Patent number
US05702641

Reaction notes

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