Potassium Carbonate → HCID 54053265, compound
Reaction equation
[CH2:1]([O:8][CH2:9][C@@H:10]1[O:12][CH2:11]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(=O)([O-])[O-].[K+].[K+].[F:19][C:20]([F:43])([C:39]([F:42])([F:41])[F:40])[C:21]([F:38])([F:37])[C:22]([F:36])([F:35])[O:23][C:24]([F:34])([F:33])[C:25]([F:32])([F:31])[C:26]([F:30])([F:29])[CH2:27][OH:28]>>[CH2:1]([O:8][CH2:9][C@@H:10]([OH:12])[CH2:11][O:28][CH2:27][C:26]([F:29])([F:30])[C:25]([F:31])([F:32])[C:24]([O:23][C:22]([F:35])([F:36])[C:21]([F:37])([F:38])[C:20]([F:43])([F:19])[C:39]([F:42])([F:41])[F:40])([F:34])[F:33])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1Participants
4
Conditions
- Temperature
- 120 °C
Procedure
(R)-Benzylglycidyl ether (2.0 g, 12.2 mmol, prepared essentially as described by Byun et al. in Tet. Lett. 30, 2751 (1989)) was added dropwise to a 120° C. solution of potassium carbonate (0.17 g, 1.2 mmol) in 4-nonafluorobutoxy-2,2,3,3,4,4-hexafluoro-1-butanol (5.1 g, 12.2mmol). The resulting mixture was stirred for 3 hours at 120° C. and was then cooled to ambient temperature and distilled (0.6 torr, 110°-130° C.) to give 6.25 g of 1-benzyloxy-(R)-2-hydroxy-3-(4-(nonafluorobutoxy)-2,2,3,3,4,4-hexafluorobutoxy)propane.
Workup
- temperaturewas then cooled to ambient temperature
- distillationdistilled (0.6 torr, 110°-130° C.)
Sources & evidence
- ORD record
- ord-a52799dcca9a4a84a59a196697147f30
- Source dataset
- uspto-grants-1997_12
- Patent number
- US05702637
Reaction notes
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