Potassium Carbonate → HCID 21460408, compound

HRID 1941220Notes

Reaction equation

HRID 1941220 reaction equation
[N:1]([C:4]1([C:9](Cl)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]1)=[N+:2]=[N-:3].[CH2:12]([O:19][CH2:20][CH2:21][NH2:22])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O-])([O-])=O.[K+].[K+]>CC(C)=O>[N:1]([C:4]1([C:9]([NH:22][CH2:21][CH2:20][O:19][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)=[O:10])[CH2:8][CH2:7][CH2:6][CH2:5]1)=[N+:2]=[N-:3]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 5338682-(Benzyloxy)ethanamineHCID 21460396HCID 21460396, compound

Product 1

HCID 21460408HCID 21460408, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

1-Azidocyclopentan-1-carbonylchloride (16.8 g) was added to a mixture of 2-benzyloxyethylamine (14.7 g), K2CO3 (16.6 g) and acetone at 0° C. After stirring at room temperature for 2 h the mixture was filtered, concentrated in vacuo and after addition water (100 ml) extracted with diethyl ether (2×100 ml).The combined organic phases were washed with brine and dried (Na2SO4). Evaporation of the solvents gave the crude 12a as an oil: 22.3 g.

Workup

  1. filtrationwas filtered
  2. concentrationconcentrated in vacuo
  3. additionafter addition water (100 ml)
  4. extractionextracted with diethyl ether (2×100 ml).The combined organic phases
  5. washwere washed with brine
  6. dry with materialdried (Na2SO4)
  7. customEvaporation of the solvents

Sources & evidence

ORD record
ord-6df9a75260964f609c7c78a6da9fbd30
Source dataset
uspto-grants-1997_12
Patent number
US05703087

Reaction notes

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