Methanol → 2-{4-Fluoro-alpha-[(2-methylquinazolin-5-yl)amino]-2-methoxybenzyl}-1,1,1-trifluoro-4-methylpentan-2-ol
Reaction equation
[CH3:33][CH2:34][O:35][C:36](=[O:37])[CH3:38].[CH3:39][CH2:40][N:41]([CH2:42][CH3:43])[CH2:44][CH3:45].[CH3:46][OH:47].[F:1][c:2]1[cH:3][c:4]([O:31][CH3:32])[c:5]([CH:6]([NH:7][c:8]2[c:9]3[cH:10][n:11][c:12]([CH3:18])[n:13][c:14]3[cH:15][cH:16][cH:17]2)[C:19]([C:20]([F:21])([F:22])[F:23])([CH2:24][C:25](=[CH2:26])[CH3:27])[OH:28])[cH:29][cH:30]1>>[F:1][c:2]1[cH:3][c:4]([O:31][CH3:32])[c:5]([CH:6]([NH:7][c:8]2[c:9]3[cH:10][n:11][c:12]([CH3:18])[n:13][c:14]3[cH:15][cH:16][cH:17]2)[C:19]([C:20]([F:21])([F:22])[F:23])([CH2:24][CH:25]([CH3:26])[CH3:27])[OH:28])[cH:29][cH:30]1Participants
5
Reactant 4
Product 1
Sources & evidence
- ORD record
- ord-43f2a7d905fe420eb3e4af7ca1babf6c
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (6/10)
Reaction notes
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