Hydrochloric Acid → HCID 22880589, compound

HRID 1941307Notes

Reaction equation

HRID 1941307 reaction equation
C(OC([NH:8][C@H:9]([CH2:14][CH2:15][NH:16][S:17]([C:20]1[CH:25]=[CH:24][C:23]([CH3:26])=[CH:22][CH:21]=1)(=[O:19])=[O:18])[C:10]([O:12][CH3:13])=[O:11])=O)CCC.[ClH:27]>O1CCOCC1>[ClH:27].[NH2:8][C@H:9]([CH2:14][CH2:15][NH:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([CH3:26])=[CH:24][CH:25]=1)(=[O:19])=[O:18])[C:10]([O:12][CH3:13])=[O:11]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22880591HCID 22880591, compound

Product 1

HCID 22880589HCID 22880589, compoundYield 70%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Methyl 2(R)-(N-butyloxycarbonylamino)-4-(p-toluenesulfonylamino)butyrate (2.0 g, 5.18 mmol) was dissolved in 10 mL 4N HCl in dioxane and the solution was stirred for 1 hour and then concentrated. The residue was triturated with ether to give 1.16 g (70%) product. ES-MS: calcd M+1 287.2; found 287.0.

Workup

  1. concentrationconcentrated
  2. customThe residue was triturated with ether

Sources & evidence

ORD record
ord-7bd5d083cc3e4c808c04201d766c4ce8
Source dataset
uspto-grants-1997_12
Patent number
US05703092

Reaction notes

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