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HRID1941328

反应详情

EQUATION

反应方程式

HRID 1941328 的结构方程式

REACTANTS

反应物

2
结构：CC(C)CCN
HCID7894

3-Methyl-1-butanamine

C5H13N

结构：O=C(N[C@@H](Cc1ccccc1)[C@H]1CO1)OCc1ccccc1
HCID9861019

Phenylmethyl N-[(1S)-1-[(2S)-2-oxiranyl]-2-phenylethyl]carbamate

C18H19NO3

PRODUCTS

生成物

1
结构：CC(C)CCNC[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OCc1ccccc1
HCID10430124

未命名化合物

收率 81%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O
溶剂HCID3776

Isopropanol

C3H8O

PROCEDURE

实验过程

Part C. A solution of N-benzyloxycarbonyl 3(S)-amino-1,2-(S)-epoxy-4-phenylbutane (30.1 g, 0.10 mol) and 165mL of isoamylamine in 150 mL of isopropyl alcohol was heated to reflux for 2.5 hours. The solution was cooled to room temperature, concentrated/n vacuo and then recrystallized. The product was isolated by filtration and from ethylacetate/hexane to afford 1.7 g (81%) of N[3(S)-benzyloxycarbonylamino-2(R)-hydroxy-4-phenylbutyl]N-isoamylamine.

WORKUP

后处理

  1. temperatureto reflux for 2.5 hours
  2. concentrationconcentrated/n vacuo
  3. customrecrystallized
  4. customThe product was isolated by filtration and from ethylacetate/hexane