反应详情

4-Methoxybenzaldehyde (1.22 ml, 10 mmol) and p-toluenesulphonamide (1.71 g, 10 mmol) were refluxed in toluene (70 ml) for 5 minutes using a Dean and Stark apparatus. Reflux was maintained while BF3 (C2 H5)2O (0.05 ml, 0.4 mmol) was added via a syringe. The reaction mixture was maintained at reflux for 12 hours before being allowed to cool to room temperature whereby the title compound precipitated from the toluene. Filtration followed by recrystallisation from dichloromethane-petrol yielded N-(4-methoxybenzylidene)-toluene-p-sulphonamide as a yellow solid (0.478 g; 17%) m.p. 127° C.

1. temperatureReflux
2. additionwas added via a syringe
3. temperatureThe reaction mixture was maintained
4. temperatureat reflux for 12 hours