Water → 2-Methoxy-5-tetrazol-1-yl-benzaldehyde

HRID 1941487Notes

Reaction equation

HRID 1941487 reaction equation
[OH:1][C:2]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)=[CH:6][C:3]=1[CH:4]=[O:5].[C:15](=O)([O-])[O-].[K+].[K+].IC.O>CN(C)C=O>[CH3:15][O:1][C:2]1[CH:9]=[CH:8][C:7]([N:10]2[CH:14]=[N:13][N:12]=[N:11]2)=[CH:6][C:3]=1[CH:4]=[O:5]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 108453442-Hydroxy-5-tetrazol-1-yl-benzaldehyde

Product 1

HCID 105361692-Methoxy-5-tetrazol-1-yl-benzaldehydeYield 67%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To a solution of 2-hydroxy-5-tetrazol-1-yl-benzaldehyde (2.63 mmol) in dimethylformamide (5 ml) was added potassium carbonate (3.95 mmol) and iodomethane (3.95 mmol) and the mixture was stirred under nitrogen atmosphere for 2 h. The mixture was poured into water (100 ml) and the white solid formed filtered to afford the title compound in a 67% yield. T.l.c. (ether) Rf 0.45

Workup

  1. customthe white solid formed
  2. filtrationfiltered

Sources & evidence

ORD record
ord-6f66d059b141419389fc4c6a193de12c
Source dataset
uspto-grants-1997_12
Patent number
US05703240

Reaction notes

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